教育和工作简历
2020.10-至今,云南农业大学,教授,化学系
2018.01-2020.9,云南农业大学,副教授,化学系
2015.08-2017.12,云南农业大学,博士见习
学术兼职
中国化学学会会员
云南省微生物协会会员
食品安全风险评估委员
教学工作
研究生课程:食品营养学研究进展、细胞及分子生物学实验技术、现代食品营养学
本科生课程:有机化学、有机化学I、有机化学II、应化Seminar、有机化学实验、应用高分子化学、仪器分析实验、普通化学、普通化学实验
研究方向
农业化学基础研究及应用
食药同源化学物质基础及生物学功效
天然多糖化学生物学及其应用基础研究
管理服务工作
副院长
奖励与荣誉
云南省“兴滇英才”计划青年人才(2020年)
研究项目
国家自然科学地区基金项目“新型铁皮石斛素类微管蛋白抑制剂的挖掘及作用机理研究”(编号:31960075), 2020.01–乐鱼官网App.12,
项目负责人
国家自然科学基金青年项目“表没食子儿茶素没食子酸酯(EGCG)氧化物的选择性合成、分离及抗肿瘤活性研究”(编号:21602196),2017.01–2019.12,项目负责人
云南省农业联合专项重点项目“茶多酚纳米聚集体功能化TKIs的构建及其在靶向治疗非小细胞肺癌的应用研究”(编号:202101BD070001-028),2022.01–乐鱼官网App.12,项目负责人
云南省农业联合专项面上项目“儿茶素类化合物的化学修饰对其生物利用度屏障的作用及机理研究”(编号:2017FG001(-046)),2017.09–2020.08,项目负责人
云南省自然科学基金青年项目“化学选择性EGCG偶联氧化产物的合成及抗肿瘤活性研究”(
编号:2017FD084),2017.06–2020.05,项目负责人
代表性论文
Yan-Ping Huang#, Xiang-Dan Cuan#, Wei-wei
Zhu, Xing-Ying Yang, Yun-Li Zhao, Jun Sheng, Cheng-Ting Zi*, Xuan-Jun Wang*. An
EGCG Derivative in Combination with Nimotuzumab for the Treatment of Wild-Type
EGFR NSCLC. Int. J. Mol. Sci. 乐鱼官网App, 24 (18), 14012.
Jia-Min Xian#, Hong-Tao Hu#, Shu Yang#,
Yu-Na Wang, Zhuo-Yi Wang, Ruo-Han Zhang, Cheng-Ting Zi*, Pei-Yuan Sun*,
Jing Wang*. Inhibitory Effect of Magnolol on Activation of EGFR L858R/T790M/G796R. BJSTR.,
乐鱼官网App, 50 (3), 41660-41666.
Liu Yang#, ChengTing Zi#,
Ding-Kang Chen, Jin-Yu Li, Rui He, Jiang-Miao Hu*. Target acquisition of
anti-aging manno-oligosaccharide that triggers ECM process via
TGF-β/Smads-SIRT1 signalling pathway. Carbohyd. Polym. 2022, 22,
120380.
Cheng-Ting Zi#, Yin-Rong Xie#, Yun
Niu#, Zhen-Hao Liu, Liu Yang, Yong-Kai Xi, Zhen-Jie Li, Feng-Mei Zhang,
Ze-Min Xiang*, Jun Sheng*. Novel cannabidiol (CBD) derivatives: Synthesis,
anti-inflammatory activity, and molecular docking. Phytochem. Lett. 2022,
51, 97–103.
Xiu-Li Sun#, Ze-Min Xiang#, Yin-Rong Xie#,
Ning Zhang, Li-Xia Wang, Yi-Long Wu, Dong-Ying Zhang, Xuan-Jun Wang*, Jun Sheng*, Cheng-Ting
Zi*. Dimeric-(-)-eigallocatechin-3-gallate inhibits the proliferation of
lung cancer cells by inhibiting the EGFR signaling pathway. Chem-Biol.
Interact. 2022, 365, 110084.
Yan-Ping Huang#, Xiang-Dan Cuan#, Xing-Ying
Yang, Wei-Wei Zhu, Yun-Li Zhao, Li Jiang, Cheng-Ting Zi*, Xuan-Jun
Wang*, Jun Sheng*. Oxidized tea polyphenol (OTP-3) targets EGFR
synergistic nimotuzumab at inhibition of non-small cell lung tumor growth. Bioorg.
Chem. 2022, 128, 106084.
Si-Si Chen#, Liu Yang#, Xia Qu#, Jin-Yu Li#, Cheng-Ting
Zi, Hao Wang*, Jiang-Miao Hu*, Ye Liu*. A new polysaccharide platform
constructs self-adjuvant nanovaccines to enhance immune responses. J. Nanobiotechnol. 2022,
20, 320.
Ye-Wei Huang#, Jing-Yun Yan#, Xiu-Li Sun#,
Yun Niu, Wen-Jun Yuan, Ling-Bin Kong, Xiang-Dong Qin, Cheng-Ting Zi*,
Xuan-Jun Wang*, Jun Sheng*. Anticancer effects of dendrocandin (DDCD)
against AKT in Hpeg2 cells using Molecular Modeling, DFT and in Vitro Study. Struct.
Chem. 2022, 33, 1331–1340.
Ning Zhang#, Yi-Long Wu#, Miao Qiao,
Wen-Juan Yuan, Xing-Yu Li, Xuan-Jun Wang*, Jun Sheng*, Cheng-Ting Zi*. Structure–antioxidant
activity relationships of dendrocandin analogues determined using
density functional theory. Struct. Chem. 2022, 33, 795–805.
Li-Xia Wang#, Ze-Hao Wang, Xiu-Li Sun, Cheng-Ting
Zi*, Xuan-Jun Wang*, Jun Sheng*. Discovery of EGFR-Targeted
Environment-Sensitive Fluorescent Probes for Cell Imaging and Efficient Tumor
Detection. Bioorg. Chem. 2022. 121, 105585.Published: 2022-01-04
Ya Wang#, Xiao-Jing Shen#, Fa-Wu Su#,
Yin-Rong Xie, Li-Xia Wang, Ning Zhang, Yi-Long Wu , Yun Niu, Dong-Ying
Zhang, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng. Novel
per-butyrylated glucoses derivatives of (-)-epigallocatechin-3-gallate inhibit
cancer cells proliferation by decreasing phosphorylation of the EGFR:
Synthesis, cytotoxicity and molecular docking. Molecules. 2021, 26 (14)
4361.
Cheng-Ting Zi#, Ze-Hao Wang#, Jing Shi#,
Boya Shi, Ning Zhang, Yi-Ling Wu, Yin-Rong Xie, Lu Zhou, Chun Xiao*, Xuan-Jun
Wang*, Jun Sheng*. Synthesis, cytotoxicity and molecular docking of
methylated (-)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin
derivatives as novel antitumor agents. J. Chem. Res. 2021:1–7.
Ze-Hao Wang#, Li-Xia Wang#, Bo-Ya Shi,
Xiu-Li Sun, Yin-Rong Xie, Hao-Nan Yang, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun
Sheng*. Demethyleneberberine promotes apoptosis and suppresses TGF-β/Smads
induced EMT in the colon cancer cells HCT-116. Cell Biochem. Fun. 2021:
1–8.
Bo-Ya Shi#, Ze-Hao Wang#, Ning Zhang, Yin-Rong
Xie, Xiu-Li Sun, Hao-Nan Yang, Yi-Long Wu, Cheng-Ting Zi*, Xuan-Jun
Wang*, Jun Sheng*. Synthesis and Anticancer Activity of Glucosylated novel
(-)-Epigallocatechin-3-gallate Derivatives Linked via Triazole Rings. Med.
Chem. Res. 2021, 30: 1240–1248.
Jing-Yun Yan#, Hao-Nan Yang#, Ning Yang,
Yin-Rong Xie, Xiu-Li Sun, Ye-Wei Huang, Cheng-Ting Zi*, Xuan-Jun Wang*,
Jun Sheng*. Synthesis and in vitro biological evaluation of novel
dendrocandin analogue as potential anti-tumor agent. Nat. Prod. Res. 2021:1–6.
Boya Shi, Zehao Wang, Xuanjun Wang, Jun
Sheng*, Chengting Zi*. Recent progress of small-molecule epidermal
growth factor receptor (EGFR) inhibitors. Med. Res. 20202020, 4
(200011), 1–4.
Canpeng Li#, Yuxun Lu#, Chengting Zi#,
Yuting Zhao, Hui Zhao*, Yaping Zhang*. Cationic pillar[6]arene induces
cell apoptosis by inhibiting protein tyrosine phosphorylation via
host-guest recognition. Int. J. Mol. Sci. 2020, 21, 7949.
Chengting Zi#, Liu Yang#, Yue Hu,
Pan Zhang, Han Tang, Banglei Zhang, Xiaojing Shen, Qinghua Kong, Ya Wang*, Xuanjun
Wang*, Jun Sheng*. Synthesis, antitumor activity, and molecular
docking of (-)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates. J.
Asin Nat. Prod. Res. 2021, 23 (8), 772-780.
Chengting Zi#, Peiyuan Sun#, Ning
Zhang, Han Tang, Haonan Yang, Qi Wang, Yuna Wang, Jing Wang*, Xuanjun Wang*, Jun
Sheng*. Glucosylated (-)-Epigallocatechin-3-gallate (EGCG) derivative via
triazole ring: Synthesis and combined with cisplatin/paclitaxel inhibits NSCLC
cancer cells by decreasing phosphorylation of the EGFR. J. Chem. Res. 2020,
44 (9-10) 586–591.
Yuna Wang#, Jing Wang#, Hao-Nan Yang,
Bang-Lei Zhang, Pan Zhang, Pei-Yuan Sun, Ning Zhang, Ya Wang, Jun Sheng*,
Xuan-Jun Wang*, Cheng-Ting Zi*. The oxidation of
(-)-epigallocatechin-3-gallate inhibits T-Cell Acute Lymphoblastic Leukemia
cell line HPB-ALL via the regulation of Notch1 expression. RSC Adv. 2020, 10,
1679–1684.
代表性著作
参编《有机化学》
参编《普通化学与定量分析化学学习指导及习题解答》等书
专利及标准
盛军,王宣军,字成庭,王晶,向泽敏,黄业伟,王娅,吴晓云,方崇业,刘佳,张冬英,汪琦,唐晗,张帮磊,王玉娜.表没食子儿茶素没食子酸酯糖苷衍生物及其应用,专利公开号:CN201810094218.6
盛军,王宣军,黄艳苹,字成庭,向泽敏,黄业伟,赵云丽,爨向丹,徐欢欢,罗瑞. 表没食子儿茶素没食子酸酯糖苷衍生物及其应用,专利公开号:CN 110038006 A
字成庭,盛军,王宣军,燕静云,杨豪男,张帮磊,胡月,杨宁,张宁,吴以龙.铁皮石斛素类似物及其制备方法和用途.专利公开号:CN 112266377
A
字成庭,盛军,王宣军,张宁,杨豪男,袁文娟,乔妙,孙秀丽.一种铁皮石斛素及其制备方法.专利公开号:CN 113045536
盛军,字成庭,王宣军,袁文娟,孙秀丽,张帮磊,杨豪男,谢引荣,燕静云,胡月,张宁,杨宁.铁皮石斛素及其制备抗癌药物的应用.专利公开号:CN 112979608
A
盛军,字成庭,王宣军,袁文娟,孙秀丽,谢引荣,杨豪男,王丽霞,张宁,吴以龙,施博雅,王泽昊.铁皮石斛素及其用途.专利公开号:CN 112939928 A
字成庭,盛军,王宣军,张宁,吴以龙.一种用于电化学工作站检测的多功能电解池.专利号:ZL
2020 2 2833997.2申请时间:2020.12.01授权时间:2021.10.19
字成庭,盛军,王宣军,吴以龙,张宁.一种用于分离茶多糖和聚合多酚的装置.专利号:ZL
2020 2 3008416.8
学生工作
指导已经毕业研究生5名,在读研究生5名,发表论文22篇。
指导本科生30名,本科生与发表科研论文8篇。